Type 2 Fibroblast Growth Factor Receptor

A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).

Also Known As:

Fibroblast Growth Factor Receptor 2; Receptor, Fibroblast Growth Factor, Type 2; BEK Fibroblast Growth Factor Receptor; BEK Fibroblast Growth Factor Receptor Kinase; BEK Protein Tyrosine Kinase; Bek Fgf Receptor Kinase; Bek-Related Fibroblast Growth Factor-Receptor-1; CD332 Antigen; FGFR2 Protein; FGFR2b; FGFR2c; Fibroblast Growth Factor Receptor 2b; Fibroblast Growth Factor Receptor 2c; Fibroblast Growth Factor Receptors 2; Fibroblast Growth Factor Receptors 2b; Receptor, Fibroblast Growth Factor 2b; Receptor, Fibroblast Growth Factor 2c; Antigen, CD332; Bek Related Fibroblast Growth Factor Receptor 1

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        Type 2 Fibroblast Growth Factor Receptor: 511
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        Type 2 Fibroblast Growth Factor Receptor: 511
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Fibroblast Growth Factor Receptors: 1653
        Type 2 Fibroblast Growth Factor Receptor: 511
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        Type 2 Fibroblast Growth Factor Receptor: 511

Jochen Wilhem Selected Research

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Disease

Drug/Important Bio-Agent (IBA)